| First Author | al-Fakhri N | Year | 1995 |
| Journal | Anat Embryol (Berl) | Volume | 192 |
| Issue | 3 | Pages | 257-64 |
| PubMed ID | 8651510 | Mgi Jnum | J:29481 |
| Mgi Id | MGI:77013 | Doi | 10.1007/BF00184750 |
| Citation | al-Fakhri N, et al. (1995) Activity of acetylcholinesterase and unspecific cholinesterase during differentiation of somites in mouse embryos. Anat Embryol (Berl) 192(3):257-64 |
| abstractText | During the development of somites in mouse embryos, widespread activity of unspecific cholinesterase (BuChE) was demonstrated after prolonged incubation. Independent of their position, all somite cells and their derivatives (dermatome, myotome and sclerotome) exhibited enzyme activity in the perinuclear space and in the endoplasmic reticulum. The plasmalemma did not show any enzyme activity. Differentiation of the sclerotome into vertebrae was accompanied by a reduction of BuChE. However, a low enzyme reaction was still present in the first typical differentiated chondroblasts. Notochordal cells were detectable by their high BuChE content. This was also found in cells already showed severe degeneration. In addition to BuChE, acetylcholinesterase (AChE) was first visible of day 9 of embryonic development in newly formed myotubes of the myotomes. Some hypotheses on the functional significance of of embryonic BuChE are discussed in the light of these results. |
