| First Author | Wagner U | Year | 1997 |
| Journal | FEBS Lett | Volume | 411 |
| Issue | 2-3 | Pages | 369-72 |
| PubMed ID | 9271238 | Mgi Jnum | J:42129 |
| Mgi Id | MGI:1095215 | Doi | 10.1016/s0014-5793(97)00733-3 |
| Citation | Wagner U, et al. (1997) Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells. FEBS Lett 411(2-3):369-72 |
| abstractText | Tau is a neuronal microtubule-associated protein whose function is modulated by phosphorylation. GSK-3beta is a tau kinase. GSK-3beta is part of the wingless signalling pathway and stimulation by wingless is predicted to down-regulate GSK-3beta activity. In Drosophila imaginal disc cells, overexpression of dishevelled, a component of the wingless pathway, mimics the wingless signal. We have therefore studied the effect that overexpression of the murine dishevelled-1 protein has on GSK-3beta-mediated phosphorylation of tau in transfected CHO cells. We find that co-transfection with dishevelled-1 is inhibitory to GSK-3beta-mediated tau phosphorylation. Tau is hyperphosphorylated in Alzheimer's disease and the possible relevance of these findings to Alzheimer's disease pathogenesis are discussed. |
