| First Author | Wang CR | Year | 1993 |
| Journal | Proc Natl Acad Sci U S A | Volume | 90 |
| Issue | 7 | Pages | 2784-8 |
| PubMed ID | 8464890 | Mgi Jnum | J:4408 |
| Mgi Id | MGI:52901 | Doi | 10.1073/pnas.90.7.2784 |
| Citation | Wang CR, et al. (1993) HMT, encoded by H-2M3, is a neoclassical major histocompatibility class I antigen. Proc Natl Acad Sci U S A 90(7):2784-8 |
| abstractText | H-2M3 encodes HMT, the major histocompatibility complex (MHC) class I heavy chain of the maternally transmitted antigen (Mta). Like classical MHC class I genes, the expression of M3 can be stimulated by gamma-interferon and its message can be detected from mid-gestational embryos (day 8) through adulthood. HMTb, a nonimmunogenic allelic form of HMT, differs from the common HMTa molecule by four amino acids, of which only two (residues 31 and 95) are located in the alpha 1 and alpha 2 domains that form the peptide-binding groove. Recognition of site-directed mutants by Mta-specific cytotoxic T lymphocytes was hardly affected by the substitution of Met for Val31 but was abolished by the substitution of Gln for Leu95, which is located in the beta-sheet floor of the peptide-binding groove. Thus a single amino acid difference is responsible for the immunological silence of HMTb. |
