| First Author | Dixit R | Year | 2008 |
| Journal | Science | Volume | 319 |
| Issue | 5866 | Pages | 1086-9 |
| PubMed ID | 18202255 | Mgi Jnum | J:131406 |
| Mgi Id | MGI:3773602 | Doi | 10.1126/science.1152993 |
| Citation | Dixit R, et al. (2008) Differential regulation of dynein and kinesin motor proteins by tau. Science 319(5866):1086-9 |
| abstractText | Dynein and kinesin motor proteins transport cellular cargoes toward opposite ends of microtubule tracks. In neurons, microtubules are abundantly decorated with microtubule-associated proteins (MAPs) such as tau. Motor proteins thus encounter MAPs frequently along their path. To determine the effects of tau on dynein and kinesin motility, we conducted single-molecule studies of motor proteins moving along tau-decorated microtubules. Dynein tended to reverse direction, whereas kinesin tended to detach at patches of bound tau. Kinesin was inhibited at about a tenth of the tau concentration that inhibited dynein, and the microtubule-binding domain of tau was sufficient to inhibit motor activity. The differential modulation of dynein and kinesin motility suggests that MAPs can spatially regulate the balance of microtubule-dependent axonal transport. |
