| First Author | Dyson PJ | Year | 1992 |
| Journal | Immunogenetics | Volume | 35 |
| Issue | 5 | Pages | 316-23 |
| PubMed ID | 1348494 | Mgi Jnum | J:147 |
| Mgi Id | MGI:48687 | Doi | 10.1007/BF00189894 |
| Citation | Dyson PJ, et al. (1992) Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198. Immunogenetics 35(5):316-23 |
| abstractText | Tum- comprises a class of genes, mutation of which in P815 tumor cells has led to the acquisition of new cytotoxic T cell-recognized epitopes. The cells carrying the mutant alleles have impaired tumorigenicity compared with their progenitors due to in vivo induction of a cytotoxic T-cell response specific for tum- antigens. Two tum- genes, P91A and P35B, were found to be single copy loci mapping to chromosomes 11 and 15 respectively. A third, P198, was found to map to chromosome 7 and to be a member of a small gene family with other members on chromosomes 13, 14, and 15. Multiple P198-related sequences were found in other mammalian species suggesting the P198 related gene family is a general feature of mammalian genomes. |
