| First Author | Chauvet V | Year | 2004 |
| Journal | J Clin Invest | Volume | 114 |
| Issue | 10 | Pages | 1433-43 |
| PubMed ID | 15545994 | Mgi Jnum | J:94419 |
| Mgi Id | MGI:3512725 | Doi | 10.1172/JCI21753 |
| Citation | Chauvet V, et al. (2004) Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J Clin Invest 114(10):1433-43 |
| abstractText | Polycystin-1, which is encoded by a gene that is mutated in autosomal dominant polycystic kidney disease (ADPKD), is involved in cell-matrix interactions as well as in ciliary signaling. The precise mechanisms by which it functions, however, remain unclear. Here we find that polycystin-1 undergoes a proteolytic cleavage that releases its C-terminal tail (CTT), which enters the nucleus and initiates signaling processes. The cleavage occurs in vivo in association with alterations in mechanical stimuli. Polycystin-2, the product of the second gene mutated in ADPKD, modulates the signaling properties of the polycystin-1 CTT. These data reveal a novel pathway by which polycystin-1 transmits messages directly to the nucleus. |
