| First Author | Fitzpatrick VD | Year | 1994 |
| Journal | J Biol Chem | Volume | 269 |
| Issue | 40 | Pages | 24621-6 |
| PubMed ID | 7929134 | Mgi Jnum | J:20662 |
| Mgi Id | MGI:68738 | Doi | 10.1016/s0021-9258(17)31437-0 |
| Citation | Fitzpatrick VD, et al. (1994) 6agonist selectivity determinants in somatostatin receptor subtypes I and II. J Biol Chem 269(40):24621-6 |
| abstractText | The biological activities of the peptide hormone somatostatin are mediated through a recently identified family of G-protein-linked receptors. A number of somatostatin analogs have been characterized with selective affinities for particular somatostatin receptor subtypes. Using one such molecule (MK-678), we have delineated receptor regions that determine analog selectivity in the murine Type 1 and Type 2 somatostatin receptors. We find that the regions about the second and third extracellular loops of these two receptors contain the determinants for MK-678 selectivity and affinity. |
