| First Author | Sato H | Year | 1995 |
| Journal | Biochem Biophys Res Commun | Volume | 214 |
| Issue | 2 | Pages | 468-74 |
| PubMed ID | 7677753 | Mgi Jnum | J:28974 |
| Mgi Id | MGI:76511 | Doi | 10.1006/bbrc.1995.2310 |
| Citation | Sato H, et al. (1995) Repression of p53-dependent sequence-specific transactivation by MEF2c. Biochem Biophys Res Commun 214(2):468-74 |
| abstractText | Lambda ZAP cDNA library constructed from spleen of a p53-deficient mouse was screened by South-Western technique using Fragment A, a DNA sequence that p53 specifically binds to, as a probe. One (clone 2) of six clones isolated was identical to MEF2c, a MADS-family transcription factor. Transcripts of the mef2c gene was also detected in spleen where the expression has not been reported so far. Isolated clones except clone 2 had a growth-suppression activity on p53-deficient osteosarcoma cell line (Saos II). Clone 2 repressed the transactivation from Fragment A by p53, suggesting that MEF2c may act as a negative regulator of p53-responsive element. |
