| First Author | Hebrok M | Year | 1994 |
| Journal | Dev Biol | Volume | 165 |
| Issue | 2 | Pages | 537-44 |
| PubMed ID | 7958419 | Mgi Jnum | J:21111 |
| Mgi Id | MGI:69156 | Doi | 10.1006/dbio.1994.1273 |
| Citation | Hebrok M, et al. (1994) M-twist is an inhibitor of muscle differentiation. Dev Biol 165(2):537-44 |
| abstractText | The twist gene encodes a transcription factor containing a conserved basic helix-loop-helix domain. During development, transcription factors of this type are normally associated with the induction of differentiation. Yet the expression pattern of the murine M-twist suggests an inhibitory role during muscle differentiation. Following stable transfection of myogenic mouse cells with an M-twist expression vector, 75% of M-twist-expressing clones were impaired in their ability to differentiate. In contrast, only 15% of control clones were unable to differentiate. Treatment with antisense oligonucleotides restored differentiation capacity in a concentration-dependent manner. Control oligonucleotides had no effect. These experiments show that the mouse twist gene can act as an inhibitor of muscle differentiation and that this inhibition is reversible. |
