| First Author | Winder DG | Year | 1999 |
| Journal | Neuron | Volume | 24 |
| Issue | 3 | Pages | 715-26 |
| PubMed ID | 10595521 | Mgi Jnum | J:263472 |
| Mgi Id | MGI:6189622 | Doi | 10.1016/s0896-6273(00)81124-1 |
| Citation | Winder DG, et al. (1999) ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors. Neuron 24(3):715-26 |
| abstractText | MAP kinase (ERK) translates cell surface signals into alterations in transcription. We have found that ERK also regulates hippocampal neuronal excitability during 5 Hz stimulation and thereby regulates forms of long-term potentiation (LTP) that do not require macromolecular synthesis. Moreover, ERK-mediated changes in excitability are selectively required for some forms of LTP but not others. ERK is required for the early phase of LTP elicited by brief 5 Hz stimulation, as well as for LTP elicited by more prolonged 5 Hz stimulation when paired with beta1-adrenergic receptor activation. By contrast, ERK plays no role in LTP elicited by a single 1 s 100 Hz train. Consistent with these results, we find that ERK is activated by beta-adrenergic receptors in CA1 pyramidal cell somas and dendrites. |
