| First Author | Simsek-Duran F | Year | 2004 |
| Journal | Nat Neurosci | Volume | 7 |
| Issue | 12 | Pages | 1296-8 |
| PubMed ID | 15543142 | Mgi Jnum | J:95111 |
| Mgi Id | MGI:3525037 | Doi | 10.1038/nn1348 |
| Citation | Simsek-Duran F, et al. (2004) Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum. Nat Neurosci 7(12):1296-8 |
| abstractText | Long-term potentiation (LTP) of granule cell-Purkinje cell synapses in the mouse cerebellum requires phosphorylation by protein kinase A of the active-zone protein RIM1alpha at Ser413. Here, we show that the adapter protein 14-3-3 readily binds phosphorylated Ser413 in RIM1alpha, and that presynaptic transfection with a dominant-negative 14-3-3eta mutant, or a RIM1alpha mutant with enhanced 14-3-3 binding, inhibits LTP. Thus, RIM1alpha phosphorylation triggers presynaptic LTP in part through recruitment of 14-3-3 to phospho-Ser413-RIM1alpha. |
