| First Author | Kellner Y | Year | 2016 |
| Journal | Hippocampus | Volume | 26 |
| Issue | 6 | Pages | 816-31 |
| PubMed ID | 26748478 | Mgi Jnum | J:347338 |
| Mgi Id | MGI:7622142 | Doi | 10.1002/hipo.22565 |
| Citation | Kellner Y, et al. (2016) Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics. Hippocampus 26(6):816-31 |
| abstractText | Nogo-A and its receptors have been shown to control synaptic plasticity, including negatively regulating long-term potentiation (LTP) in the cortex and hippocampus at a fast time scale and restraining experience-dependent turnover of dendritic spines over days. However, the molecular mechanisms and the precise time course mediating these actions of Nogo-A are largely unexplored. Here we show that Nogo-A signaling in the adult nervous system rapidly modulates the spine actin cytoskeleton within minutes to control structural plasticity at dendritic spines of CA3 pyramidal neurons. Indeed, acute Nogo-A loss-of-function transiently increases F-actin stability and results in an increase in dendritic spine density and length. In addition, Nogo-A acutely restricts AMPAR insertion and mEPSC amplitude at hippocampal synaptic sites. These data indicate a crucial function of Nogo-A in modulating the very tight balance between plasticity and stability of the neuronal circuitry underlying learning processes and the ability to store long-term information in the mature CNS. (c) 2016 Wiley Periodicals, Inc. |
