| First Author | Pan X | Year | 2019 |
| Journal | Cell Rep | Volume | 26 |
| Issue | 8 | Pages | 1988-1999.e6 |
| PubMed ID | 30784582 | Mgi Jnum | J:288396 |
| Mgi Id | MGI:6431942 | Doi | 10.1016/j.celrep.2019.01.084 |
| Citation | Pan X, et al. (2019) MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon. Cell Rep 26(8):1988-1999.e6 |
| abstractText | The motor protein kinesin-1 plays an important role in polarized sorting of transport vesicles to the axon. However, the mechanism by which the axonal entry of kinesin-1-dependent cargo transport is regulated remains unclear. Microtubule-associated protein MAP7 (ensconsin in Drosophila) is an essential kinesin-1 cofactor and promotes kinesin-1 recruitment to microtubules. Here, we found that MAP7 family member MAP7D2 concentrates at the proximal axon, where it overlaps with the axon initial segment and interacts with kinesin-1. Depletion of MAP7D2 results in reduced axonal cargo entry and defects in axon development and neuronal migration. We propose a model in which MAP7D2 in the proximal axon locally promotes kinesin-1-mediated cargo entry into the axon. |
