| First Author | Chattopadhyay N | Year | 2003 |
| Journal | J Cell Biol | Volume | 163 |
| Issue | 6 | Pages | 1351-62 |
| PubMed ID | 14691142 | Mgi Jnum | J:273548 |
| Mgi Id | MGI:6294221 | Doi | 10.1083/jcb.200306067 |
| Citation | Chattopadhyay N, et al. (2003) alpha3beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPmu expression and cell-cell adhesion. J Cell Biol 163(6):1351-62 |
| abstractText | The beta1 family of integrins has been primarily studied as a set of receptors for the extracellular matrix. In this paper, we define a novel role for alpha3beta1 integrin in association with the tetraspanin CD151 as a component of a cell-cell adhesion complex in epithelial cells that directly stimulates cadherin-mediated adhesion. The integrin-tetraspanin complex affects epithelial cell-cell adhesion at the level of gene expression both by regulating expression of PTPmu and by organizing a multimolecular complex containing PKCbetaII, RACK1, PTPmu, beta-catenin, and E-cadherin. These findings demonstrate how integrin-based signaling can regulate complex biological responses at multiple levels to determine cell morphology and behavior. |
