| First Author | Riera J | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 16 | Pages | 3057-62 |
| PubMed ID | 17555748 | Mgi Jnum | J:123614 |
| Mgi Id | MGI:3718915 | Doi | 10.1016/j.febslet.2007.05.065 |
| Citation | Riera J, et al. (2007) Isolation and characterization of nudC from mouse macrophages, a gene implicated in the inflammatory response through the regulation of PAF-AH(I) activity. FEBS Lett 581(16):3057-62 |
| abstractText | We report the characterization of a cDNA induced in mouse macrophages that encodes a 332-amino acid protein with extensive sequence identity with members of the mammalian nudC-like genes. The interaction between mNUDC and the regulatory beta subunit of platelet activating factor acetylhydrolase I (PAF-AH(I)) shown in this article indicates a new function of NUDC. Thus, we show that NUDC increases the catalytic activity of PAF-AH(I) and that this regulatory activity is located in the carboxyl terminal half of the protein which is highly conserved. This suggests a novel function for mammalian nudC-like genes as anti-inflammatory proteins. |
