| First Author | Liu Y | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 17 | Pages | 2859-66 |
| PubMed ID | 24997346 | Mgi Jnum | J:213636 |
| Mgi Id | MGI:5585527 | Doi | 10.1016/j.febslet.2014.06.049 |
| Citation | Liu Y, et al. (2014) FERM domain-containing unconventional myosin VIIA interacts with integrin beta5 subunit and regulates alphavbeta5-mediated cell adhesion and migration. FEBS Lett 588(17):2859-66 |
| abstractText | Unconventional myosin VIIA (Myo7a) has been known to associate with hereditary deafness. Here we present a novel function of Myo7a by identifying that Myo7a directly interacts with integrin beta5 subunit and regulates cell adhesion and motility in an integrin-dependent manner. We found that Myo7a bound to the cytoplasmic tail of integrin beta5. Further, we pinpointed an integrin-binding domain at F3 of the first FERM domain and F1 of the second FERM domain. Functionally, Myo7a-induced cell adhesion and migration were mediated by integrin alphavbeta5. These findings indicated that Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration. |
