| First Author | Cheng P | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 20 Pt B | Pages | 3079-84 |
| PubMed ID | 25962847 | Mgi Jnum | J:226000 |
| Mgi Id | MGI:5695430 | Doi | 10.1016/j.febslet.2015.04.049 |
| Citation | Cheng P, et al. (2015) Tumor suppressor Menin acts as a corepressor of LXRalpha to inhibit hepatic lipogenesis. FEBS Lett 589(20 Pt B):3079-84 |
| abstractText | Menin, encoded by the MEN1 gene, was initially identified as a tumor suppressor for endocrine neoplasia. Our previous report showed that Menin enhances PPARalpha transactivity preventing triglyceride accumulation in the liver. Here, we further explore the role of Menin in liver steatosis. Transient transfection assays demonstrate that Menin inhibits the transcriptional activity of nuclear receptor liver X receptor alpha (LXRalpha). Accordingly, Menin overexpression results in reduced expression of LXRalpha target genes, such as lipogenic enzymes including SREBP-1c, FASN and SCD-1. Co-immunoprecipitation assays revealed physical interaction between Menin and LXRalpha. Collectively, our data suggest that Menin acts as a novel corepressor of LXRalpha and functions as a negative regulator of hepatic lipogenesis. |
