| First Author | Hadjihannas MV | Year | 2012 |
| Journal | EMBO Rep | Volume | 13 |
| Issue | 4 | Pages | 347-54 |
| PubMed ID | 22322943 | Mgi Jnum | J:200483 |
| Mgi Id | MGI:5508712 | Doi | 10.1038/embor.2012.12 |
| Citation | Hadjihannas MV, et al. (2012) Cell cycle control of Wnt/beta-catenin signalling by conductin/axin2 through CDC20. EMBO Rep 13(4):347-54 |
| abstractText | Wnt/beta-catenin signalling regulates cell proliferation by modulating the cell cycle and is negatively regulated by conductin/axin2/axil. We show that conductin levels peak at G2/M followed by a rapid decline during return to G1. In line with this, Wnt/beta-catenin target genes are low at G2/M and high at G1/S, and beta-catenin phosphorylation oscillates during the cell cycle in a conductin-dependent manner. Conductin is degraded by the anaphase-promoting complex/cyclosome cofactor CDC20. Knockdown of CDC20 blocks Wnt signalling through conductin. CDC20-resistant conductin inhibits Wnt signalling and attenuates colony formation of colorectal cancer cells. We propose that CDC20-mediated degradation of conductin regulates Wnt/beta-catenin signalling for maximal activity during G1/S. |
