| First Author | Gómez-Gonzalo M | Year | 2004 |
| Journal | Virology | Volume | 328 |
| Issue | 1 | Pages | 120-30 |
| PubMed ID | 15380363 | Mgi Jnum | J:218000 |
| Mgi Id | MGI:5616323 | Doi | 10.1016/j.virol.2004.06.044 |
| Citation | Gomez-Gonzalo M, et al. (2004) Hepatitis C virus core protein regulates p300/CBP co-activation function. Possible role in the regulation of NF-AT1 transcriptional activity. Virology 328(1):120-30 |
| abstractText | Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Oncogenic virus proteins often target p300/CBP, a known co-activator of a wide variety of transcription factors, to regulate the expression of cellular and viral genes. Here we demonstrate, for the first time, that HCV core protein interacts with p300/CBP and enhances both its acetyl-transferase and transcriptional activities. In addition, we demonstrate that nuclear core protein activates the NH2-terminal transcription activation domain (TAD) of NF-AT1 in a p300/CBP-dependent manner. We propose a model in which core protein regulates the co-activation function of p300/CBP and activates NF-AT1, and probably other p300/CBP-regulated transcription factors, by a novel mechanism involving the regulation of the acetylation state of histones and/or components of the transcriptional machinery. |
