| First Author | Huang T | Year | 2011 |
| Journal | J Biol Chem | Volume | 286 |
| Issue | 43 | Pages | 37399-405 |
| PubMed ID | 21880741 | Mgi Jnum | J:177735 |
| Mgi Id | MGI:5295911 | Doi | 10.1074/jbc.M111.251165 |
| Citation | Huang T, et al. (2011) Nuclear Factor of Activated T Cells (NFAT) Proteins Repress Canonical Wnt Signaling via Its Interaction with Dishevelled (Dvl) Protein and Participate in Regulating Neural Progenitor Cell Proliferation and Differentiation. J Biol Chem 286(43):37399-405 |
| abstractText | The Ca(2+) signaling pathway appears to regulate the processes of the early development through its antagonism of canonical Wnt/beta-catenin signaling pathway. However, the underlying mechanism is still poorly understood. Here, we show that nuclear factor of activated T cells (NFAT), a component of Ca(2+) signaling, interacts directly with Dishevelled (Dvl) in a Ca(2+)-dependent manner. A dominant negative form of NFAT rescued the inhibition of the Wnt/beta-catenin pathway triggered by the Ca(2+) signal. NFAT functioned downstream of beta-catenin without interfering with its stability, but influencing the interaction of beta-catenin with Dvl by its competitively binding to Dvl. Furthermore, we demonstrate that NFAT is a regulator in the proliferation and differentiation of neural progenitor cells by modulating canonical Wnt/beta-catenin signaling pathway in the neural tube of chick embryo. Our findings suggest that NFAT negatively regulates canonical Wnt/beta-catenin signaling by binding to Dvl, thereby participating in vertebrate neurogenesis. |
