| First Author | Lin S | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 8 | Pages | 1197-202 |
| PubMed ID | 18325333 | Mgi Jnum | J:201251 |
| Mgi Id | MGI:5512836 | Doi | 10.1016/j.febslet.2008.02.053 |
| Citation | Lin S, et al. (2008) CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5. FEBS Lett 582(8):1197-202 |
| abstractText | Dysfunction of E-cadherins often results in metastasis of cancerous cells. Here we show that p35, a critical regulator of cyclin-dependent kinase 5 (CDK5), specifically depletes the precursor form of E-cadherin, but not the mature form, by using a precursor-specific antibody. Most intriguingly, this downregulation of precursor E-cadherin by p35 is unequivocally independent of CDK5. Moreover, we found that p35 forms complexes with E-cadherin proteins. We also found that p35 co-expression can target E-cadherin to lysosomes and that p35-triggered disappearance of E-cadherin precursor can be blocked specifically by lysosomal protease inhibitors, indicating that p35 induces endocytosis and subsequent degradation of precursor E-cadherin. |
