| First Author | Hülsken J | Year | 1994 |
| Journal | J Cell Biol | Volume | 127 |
| Issue | 6 Pt 2 | Pages | 2061-9 |
| PubMed ID | 7806582 | Mgi Jnum | J:22125 |
| Mgi Id | MGI:70011 | Doi | 10.1083/jcb.127.6.2061 |
| Citation | Hulsken J, et al. (1994) E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol 127(6 Pt 2):2061-9 |
| abstractText | beta-Catenin is involved in the formation of adherens junctions of mammalian epithelia. It interacts with the cell adhesion molecule E-cadherin and also with the tumor suppressor gene product APC, and the Drosophila homologue of beta-catenin, armadillo, mediates morphogenetic signals. We demonstrate here that E-cadherin and APC directly compete for binding to the internal, armadillo-like repeats of beta-catenin; the NH2-terminal domain of beta-catenin mediates the interaction of the alternative E-cadherin and APC complexes to the cytoskeleton by binding to alpha-catenin. Plakoglobin (gamma-catenin), which is structurally related to beta-catenin, mediates identical interactions. We thus show that the APC tumor suppressor gene product forms strikingly similar associations as found in cell junctions and suggest that beta-catenin and plakoglobin are central regulators of cell adhesion, cytoskeletal interaction, and tumor suppression. |
