| First Author | Sciortino MT | Year | 2006 |
| Journal | Virology | Volume | 356 |
| Issue | 1-2 | Pages | 136-46 |
| PubMed ID | 16950491 | Mgi Jnum | J:118786 |
| Mgi Id | MGI:3700400 | Doi | 10.1016/j.virol.2006.08.001 |
| Citation | Sciortino MT, et al. (2006) Role of Bcl-2 expression for productive herpes simplex virus 2 replication. Virology 356(1-2):136-46 |
| abstractText | Herpes simplex viruses infect a variety of cells in vitro. However, not all infected cells sustain a fully productive replication of these viruses. We have shown that, in U937 monocytoid cells, herpes simplex virus 2 (HSV-2) causes a low-productive infection characterized by apoptosis as cytopathic effect at a late stage of infection. This effect was associated with a down-regulation of the Bcl-2 protein. We therefore asked whether destabilization of Bcl-2 expression could act as a limiting factor for the productive HSV-2 infection. We found that overexpression of Bcl-2 in U937 cells dramatically increased the capability of these cells to sustain a fully productive infection, while protecting against apoptosis induced by HSV-2. Overall, our data indicate that Bcl-2 expression acts as a regulator of HSV-2 replication. |
