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Publication : Regulation of translation initiation in eukaryotes: mechanisms and biological targets.

First Author  Sonenberg N Year  2009
Journal  Cell Volume  136
Issue  4 Pages  731-45
PubMed ID  19239892 Mgi Jnum  J:320123
Mgi Id  MGI:6869962 Doi  10.1016/j.cell.2009.01.042
Citation  Sonenberg N, et al. (2009) Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 136(4):731-45
abstractText  Translational control in eukaryotic cells is critical for gene regulation during nutrient deprivation and stress, development and differentiation, nervous system function, aging, and disease. We describe recent advances in our understanding of the molecular structures and biochemical functions of the translation initiation machinery and summarize key strategies that mediate general or gene-specific translational control, particularly in mammalian systems.
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