| First Author | Gekara NO | Year | 2004 |
| Journal | Biochem Soc Trans | Volume | 32 |
| Issue | Pt 5 | Pages | 712-4 |
| PubMed ID | 15493995 | Mgi Jnum | J:125623 |
| Mgi Id | MGI:3759338 | Doi | 10.1042/BST0320712 |
| Citation | Gekara NO, et al. (2004) Lipid rafts clustering and signalling by listeriolysin O. Biochem Soc Trans 32(Pt 5):712-4 |
| abstractText | Listeriolysin O, the major virulent determinant of Listeria monocytogenes, is known for forming pores on cholesterol-rich membranes. In the present study, we reveal its other facet, rafts clustering. By immunofluorescence microscopy, we show that the glycosylphosphatidylinositol-anchored proteins CD14 and CD24, which normally exhibit uniform distribution on J774 cells, undergo clustering upon treatment with LLO. The non-raft marker transferrin receptor is unaffected by such treatment. Rafts clustering might explain the induction of tyrosine phosphorylation observed on LLO-treated cells. |
