| First Author | Ping P | Year | 2001 |
| Journal | Circ Res | Volume | 88 |
| Issue | 1 | Pages | 59-62 |
| PubMed ID | 11139474 | Mgi Jnum | J:222156 |
| Mgi Id | MGI:5644028 | Doi | 10.1161/01.res.88.1.59 |
| Citation | Ping P, et al. (2001) Functional proteomic analysis of protein kinase C epsilon signaling complexes in the normal heart and during cardioprotection. Circ Res 88(1):59-62 |
| abstractText | Using two-dimensional electrophoresis, mass spectrometry, immunoblotting, and affinity pull-down assays, we found that myocardial protein kinase C epsilon (PKCepsilon) is physically associated with at least 36 known proteins that are organized into structural proteins, signaling molecules, and stress-responsive proteins. Furthermore, we found that the cardioprotection induced by activation of PKCepsilon is coupled with dynamic modulation and recruitment of PKCepsilon-associated proteins. The results suggest heretofore-unrecognized functions of PKCepsilon and provide an integrated framework for the understanding of PKCepsilon-dependent signaling architecture and cardioprotection. |
