| First Author | He X | Year | 1997 |
| Journal | Science | Volume | 275 |
| Issue | 5306 | Pages | 1652-4 |
| PubMed ID | 9054360 | Mgi Jnum | J:164793 |
| Mgi Id | MGI:4835157 | Doi | 10.1126/science.275.5306.1652 |
| Citation | He X, et al. (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 275(5306):1652-4 |
| abstractText | In Xenopus laevis embryos, the Wingless/Wnt-1 subclass of Wnt molecules induces axis duplication, whereas the Wnt-5A subclass does not. This difference could be explained by distinct signal transduction pathways or by a lack of one or more Wnt-5A receptors during axis formation. Wnt-5A induced axis duplication and an ectopic Spemann organizer in the presence of hFz5, a member of the Frizzled family of seven-transmembrane receptors. Wnt-5A/hFz5 signaling was antagonized by glycogen synthase kinase-3 and by the amino-terminal ectodomain of hFz5. These results identify hFz5 as a receptor for Wnt-5A. |
