| First Author | Gjörloff-Wingren A | Year | 2000 |
| Journal | Eur J Immunol | Volume | 30 |
| Issue | 8 | Pages | 2412-21 |
| PubMed ID | 10940933 | Mgi Jnum | J:169808 |
| Mgi Id | MGI:4942261 | Doi | 10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J |
| Citation | Gjorloff-Wingren A, et al. (2000) Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Eur J Immunol 30(8):2412-21 |
| abstractText | A high protein tyrosine phosphatase (PTPase) activity is required to maintain circulating T lymphocytes in a resting phenotype, and to limit the initiation of T cell activation. We report that 15 of the currently known 24 intracellular PTPases are expressed in T cells, namely HePTP, TCPTP, SHP1, SHP2, PEP, PTP-PEST, PTP-MEG2, PTEN, PTPH1, PTP-MEG1, PTP36, PTP-BAS, LMPTP, PRL-1 and OV-1. Most were found in the cytosol and many were enriched at the plasma membrane. Only TCPTP and PTP-MEG2 had subcellular localizations that essentially excludes them from a direct role in early T cell antigen receptor signaling events. Overexpression of 6 of the PTPases reduced IL-2 gene activation, 3 of them thereby identified as novel candidates for negative regulators of TCR signaling. Our findings expand the repertoire of PTPases that should be considered for a regulatory role in T cell activation. |
