| First Author | Yu FX | Year | 2014 |
| Journal | Cancer Cell | Volume | 25 |
| Issue | 6 | Pages | 822-30 |
| PubMed ID | 24882516 | Mgi Jnum | J:213875 |
| Mgi Id | MGI:5586771 | Doi | 10.1016/j.ccr.2014.04.017 |
| Citation | Yu FX, et al. (2014) Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell 25(6):822-30 |
| abstractText | Uveal melanoma (UM) is the most common cancer in adult eyes. Approximately 80% of UMs harbor somatic activating mutations in GNAQ or GNA11 (encoding Gq or G11, respectively). Herein, we show in both cell culture and human tumors that cancer-associated Gq/11 mutants activate YAP, a major effector of the Hippo tumor suppressor pathway that is also regulated by G protein-coupled receptor signaling. YAP mediates the oncogenic activity of mutant Gq/11 in UM development, and the YAP inhibitor verteporfin blocks tumor growth of UM cells containing Gq/11 mutations. This study reveals an essential role of the Hippo-YAP pathway in Gq/11-induced tumorigenesis and suggests YAP as a potential drug target for UM patients carrying mutations in GNAQ or GNA11. |
