| First Author | Christenn M | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 27 | Pages | 5173-7 |
| PubMed ID | 17950729 | Mgi Jnum | J:127744 |
| Mgi Id | MGI:3764767 | Doi | 10.1016/j.febslet.2007.10.003 |
| Citation | Christenn M, et al. (2007) Interaction of brain somatostatin receptors with the PDZ domains of PSD-95. FEBS Lett 581(27):5173-7 |
| abstractText | Using peptide affinity purification, we identified an interaction between somatostatin receptors SSTR4 and SSTR1 and PDZ domains 1 and 2 of the postsynaptic proteins postsynaptic density protein of 95kDa (PSD-95) and PSD-93. The existence of the SSTR4/PSD-95 complex was verified by coimmunoprecipitation from transfected cells and solubilized brain membranes. In neurons, dendritically localized SSTR4 partially colocalizes with postsynaptic PSD-95. As functional parameters of the receptor, such as coupling to potassium channels, are not affected by the interaction with PSD-95, the association may serve to localize the receptor to postsynaptic sites. |
