| First Author | Wong AM | Year | 2005 |
| Journal | Neurosci Lett | Volume | 390 |
| Issue | 2 | Pages | 76-80 |
| PubMed ID | 16157452 | Mgi Jnum | J:269541 |
| Mgi Id | MGI:6274946 | Doi | 10.1016/j.neulet.2005.07.058 |
| Citation | Wong AM, et al. (2005) Macrosialin increases during normal brain aging are attenuated by caloric restriction. Neurosci Lett 390(2):76-80 |
| abstractText | During normal aging, microglia develop an activated phenotype characterized by morphologic changes and induction of CD11b, MHC II, and other inflammatory markers. We show that macrosialin (CD68), a macrophage-specific protein, is increased by aging in selected brain regions of male C57BL/6NNia mice. In corpus callosum and striatum, macrosialin mRNA and protein increased >or=50% (24 months versus 4 months); hippocampus and cerebellum were unchanged. Caloric restriction (CR) attenuated these age-related increases. Since CR attenuates age-related increases in oxidative damage and inflammation, we examined whether oxidized lipoproteins and inflammatory processes regulate macrosialin using murine BV-2 microglial cells as a model. Oxidized low-density lipoproteins (oxLDL) induced macrosialin protein by 50%. Moreover, macrosialin was induced in response to lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma) which activates inflammatory pathways in BV-2 cells. Thus, the previously documented increase in oxidized lipoproteins, inflammation, and microglial activation during normal aging may contribute to the age-related increase in macrosialin expression. |
