| First Author | Hirose T | Year | 2003 |
| Journal | FEBS Lett | Volume | 534 |
| Issue | 1-3 | Pages | 133-8 |
| PubMed ID | 12527374 | Mgi Jnum | J:227393 |
| Mgi Id | MGI:5700309 | Doi | 10.1016/s0014-5793(02)03819-x |
| Citation | Hirose T, et al. (2003) Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans. FEBS Lett 534(1-3):133-8 |
| abstractText | To elucidate the primitive roles of the Src family kinases (SFKs), here we characterized Caenorhabditis elegans orthologues of SFKs (src-1 and kin-22) and their regulator kinase Csk (csk-1). SRC-1 and KIN-22 possess the C-terminal regulatory tyrosines characteristic of SFKs, and their activities are negatively regulated by CSK-1 in a yeast expression system. The src-1 and csk-1 genes are co-expressed in some head neurons, the anchor cell and the tail region, while kin-22 and csk-1 genes are co-expressed in pharyngeal muscles and tail region. Expression of KIN-22 induced morphological defects in the pharynx, whereas expression of SRC-1 did not show any overt phenotype in adult. RNA interference of src-1, but not that of kin-22, caused a developmental arrest in early development. These results suggest that SRC-1 and KIN-22 play distinct roles under the control of CSK-1. |
