| First Author | Yamazaki C | Year | 2010 |
| Journal | Biochem Biophys Res Commun | Volume | 397 |
| Issue | 4 | Pages | 756-61 |
| PubMed ID | 20541533 | Mgi Jnum | J:172940 |
| Mgi Id | MGI:5009353 | Doi | 10.1016/j.bbrc.2010.06.029 |
| Citation | Yamazaki C, et al. (2010) Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice. Biochem Biophys Res Commun 397(4):756-61 |
| abstractText | Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8alpha(+) conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8(+) T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3(+) DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8(+) T cells through XCR1. |
