| First Author | Montoye T | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 13 | Pages | 3301-7 |
| PubMed ID | 16698021 | Mgi Jnum | J:109624 |
| Mgi Id | MGI:3629374 | Doi | 10.1016/j.febslet.2006.04.094 |
| Citation | Montoye T, et al. (2006) Analysis of leptin signalling in hematopoietic cells using an adapted MAPPIT strategy. FEBS Lett 580(13):3301-7 |
| abstractText | The adipocyte-secreted hormone leptin participates in the regulation of hematopoiesis and enhances proliferation of hematopoietic cells. We used an adaptation of the MAPPIT mammalian two-hybrid method to study leptin signalling in a hematopoietic setting. We confirmed the known interactions of suppressor of cytokine signalling 3 (SOCS3) and STAT5 with the Y985 and Y1077 motifs of the leptin receptor, respectively. We also provide evidence for novel interactions at the Y1077 motif, including phospholipase C gamma and several members of the SOCS protein family, further underscoring the important role of the Y1077 motif in leptin signalling. |
