| First Author | Yoon JH | Year | 2012 |
| Journal | Mol Cell | Volume | 47 |
| Issue | 4 | Pages | 648-55 |
| PubMed ID | 22841487 | Mgi Jnum | J:352574 |
| Mgi Id | MGI:7707629 | Doi | 10.1016/j.molcel.2012.06.027 |
| Citation | Yoon JH, et al. (2012) LincRNA-p21 suppresses target mRNA translation. Mol Cell 47(4):648-55 |
| abstractText | Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitment of let-7/Ago2 to lincRNA-p21, leading to lower lincRNA-p21 stability. Under reduced HuR levels, lincRNA-p21 accumulated in human cervical carcinoma HeLa cells, increasing its association with JUNB and CTNNB1 mRNAs and selectively lowering their translation. With elevated HuR, lincRNA-p21 levels declined, which in turn derepressed JunB and beta-catenin translation and increased the levels of these proteins. We propose that HuR controls translation of a subset of target mRNAs by influencing lincRNA-p21 levels. Our findings uncover a role for lincRNA as a posttranscriptional inhibitor of translation. |
