| First Author | Lin Y | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 26 | Pages | 5151-7 |
| PubMed ID | 17937931 | Mgi Jnum | J:127098 |
| Mgi Id | MGI:3762978 | Doi | 10.1016/j.febslet.2007.09.056 |
| Citation | Lin Y, et al. (2007) Cyclin G associated kinase interacts with interleukin 12 receptor beta2 and suppresses interleukin 12 induced IFN-gamma production. FEBS Lett 581(26):5151-7 |
| abstractText | Interleukin 12 receptor beta1 (IL-12Rbeta1) and beta2 (IL-12Rbeta2) constitute the functional and high-affinity receptor complex for interleukin 12 (IL-12) and mediate important functions in activated T cells. In this study, we identified cyclin G associated kinase (GAK) as a new IL-12Rbeta2-interacting protein using yeast two-hybrid system and confirmed it by coimmunoprecipitation assays. Overexpression of GAK in activated T cells suppresses IL-12 induced IFN-gamma production but has no detectable effects on its proliferation, whereas knockdown of GAK by RNA interference (RNAi) increases IFN-gamma production. These results suggest that GAK associates with IL-12Rbeta2 and may play a role in regulating IL-12 signaling. |
