| First Author | Essers MA | Year | 2005 |
| Journal | Science | Volume | 308 |
| Issue | 5725 | Pages | 1181-4 |
| PubMed ID | 15905404 | Mgi Jnum | J:227391 |
| Mgi Id | MGI:5700307 | Doi | 10.1126/science.1109083 |
| Citation | Essers MA, et al. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308(5725):1181-4 |
| abstractText | beta-Catenin is a multifunctional protein that mediates Wnt signaling by binding to members of the T cell factor (TCF) family of transcription factors. Here, we report an evolutionarily conserved interaction of beta-catenin with FOXO transcription factors, which are regulated by insulin and oxidative stress signaling. beta-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells. In Caenorhabditis elegans, loss of the beta-catenin BAR-1 reduces the activity of the FOXO ortholog DAF-16 in dauer formation and life span. Association of beta-catenin with FOXO was enhanced in cells exposed to oxidative stress. Furthermore, BAR-1 was required for the oxidative stress-induced expression of the DAF-16 target gene sod-3 and for resistance to oxidative damage. These results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress. |
