| First Author | Yang FC | Year | 2000 |
| Journal | Immunity | Volume | 12 |
| Issue | 5 | Pages | 557-68 |
| PubMed ID | 10843388 | Mgi Jnum | J:111999 |
| Mgi Id | MGI:3655336 | Doi | 10.1016/s1074-7613(00)80207-1 |
| Citation | Yang FC, et al. (2000) Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells. Immunity 12(5):557-68 |
| abstractText | Mast cells generated from Rac2-deficient (-/-) mice demonstrated defective actin-based functions, including adhesion, migration, and degranulation. Rac2(-/-) mast cells generated lower numbers and less mast cell colonies in response to growth factors and were deficient in vivo. Rac2(-/-) mast cells demonstrated a significant reduction in growth factor-induced survival, which correlated with the lack of activation of Akt and significant changes in the expression of the Bcl-2 family members BAD and Bcl-XL, in spite of a 3-fold induction of Rac1 protein. These results suggest that Rac2 plays a unique role in multiple cellular functions and describe an essential role for Rac2 in growth factor-dependent survival and expression of BAD/Bcl-XL. |
