| First Author | Ferland-McCollough D | Year | 2012 |
| Journal | Cell Death Differ | Volume | 19 |
| Issue | 6 | Pages | 1003-12 |
| PubMed ID | 22223106 | Mgi Jnum | J:239199 |
| Mgi Id | MGI:5825423 | Doi | 10.1038/cdd.2011.183 |
| Citation | Ferland-McCollough D, et al. (2012) Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes. Cell Death Differ 19(6):1003-12 |
| abstractText | Nutrition during early mammalian development permanently influences health of the adult, including increasing the risk of type 2 diabetes and coronary heart disease. However, the molecular mechanisms underlying such programming are poorly defined. Here we demonstrate that programmed changes in miRNA expression link early-life nutrition to long-term health. Specifically, we show that miR-483-3p is upregulated in adipose tissue from low-birth-weight adult humans and prediabetic adult rats exposed to suboptimal nutrition in early life. We demonstrate that manipulation of miR-483-3p levels in vitro substantially modulates the capacity of adipocytes to differentiate and store lipids. We show that some of these effects are mediated by translational repression of growth/differentiation factor-3, a target of miR-483-3p. We propose that increased miR-483-3p expression in vivo, programmed by early-life nutrition, limits storage of lipids in adipose tissue, causing lipotoxicity and insulin resistance and thus increasing susceptibility to metabolic disease. |
