| First Author | Wang F | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 372 |
| Issue | 1 | Pages | 162-7 |
| PubMed ID | 18477474 | Mgi Jnum | J:136963 |
| Mgi Id | MGI:3797438 | Doi | 10.1016/j.bbrc.2008.05.017 |
| Citation | Wang F, et al. (2008) Varp interacts with Rab38 and functions as its potential effector. Biochem Biophys Res Commun 372(1):162-7 |
| abstractText | Varp, a novel protein containing a VPS9 domain and ankyrin repeats, can function as a guanine nucleotide exchange factor (GEF) of Rab21. We previously reported that Varp plays an important role in the regulation of endosome dynamics. To further investigate the function of Varp, a yeast two-hybrid screen was performed and Rab38 was identified as a Varp-associated protein. We demonstrate that Varp physically interacts with Rab38, and preferentially binds to the active GTP-bound form of Rab38 both in vitro and in vivo. Furthermore, Varp was shown to be recruited to Rab38-positive organelles in an ankyrin-repeat 1 (ANK1)-dependent manner. Our data demonstrate that Varp is a potential effector of Rab38. Together with our previous study, we propose Varp serves as both an effector and a GEF by interacting with different Rabs in mammalian cells. |
