| First Author | Filippello A | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 18 | Pages | 2989-95 |
| PubMed ID | 23886709 | Mgi Jnum | J:201907 |
| Mgi Id | MGI:5516151 | Doi | 10.1016/j.febslet.2013.07.018 |
| Citation | Filippello A, et al. (2013) Identification of nuclear retention domains in the RBM20 protein. FEBS Lett 587(18):2989-95 |
| abstractText | RBM20 is a nuclear protein which regulates alternative splicing of expressed genes that have a key role in cardiac function. By cloning the human and mouse RBM20 cDNA, producing expressing vectors for truncated proteins, and comparing their sub-cellular distribution in transfected cells, we have identified the sequences necessary for RBM20 full nuclear retention. The region overlaps an RNA binding motif and a serine-arginine domain. The sequence is conserved in many species but belongs only to RBM20 orthologs. The RMB20 tissue specificity, together with the properties of its nuclear localization determinant, demonstrates a specific evolutionary selection of post-transcriptional regulation factors. |
