| First Author | Hsu CH | Year | 2010 |
| Journal | Neurodegener Dis | Volume | 7 |
| Issue | 1-3 | Pages | 68-75 |
| PubMed ID | 20173330 | Mgi Jnum | J:196352 |
| Mgi Id | MGI:5487757 | Doi | 10.1159/000285509 |
| Citation | Hsu CH, et al. (2010) LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins. Neurodegener Dis 7(1-3):68-75 |
| abstractText | Increasing evidence supports a putative link between LRRK2 function and the MAP kinase cascades. We recently demonstrated that LRRK2 binds to MKK6, -3, and -7. Previous studies demonstrated that scaffold proteins are essential in the regulation of subcellular localization of stress kinase complexes. The c-jun NH2-terminal kinase (JNK)-interacting proteins (JIPs) are a group of scaffold proteins that play an important role in the regulation of MAP kinase signaling cascades. JIP1-3 are known to regulate the specificity and localization of the JNK pathway, while JIP4 is a specific scaffolding protein for the p38 pathway. We demonstrate that LRRK2 binds to JIP1-4, and is associated with increased levels of total JIP1, -3, -4, oligomeric JIP and ubiquitinated JIP. These results are consistent with a putative role of LRRK2 in regulating the stress kinase cascade. |
