| First Author | Baksh S | Year | 2002 |
| Journal | Mol Cell | Volume | 10 |
| Issue | 5 | Pages | 1071-81 |
| PubMed ID | 12453415 | Mgi Jnum | J:80577 |
| Mgi Id | MGI:2446371 | Doi | 10.1016/s1097-2765(02)00701-3 |
| Citation | Baksh S, et al. (2002) NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell 10(5):1071-81 |
| abstractText | The calcineurin-regulated transcription factor, nuclear factor of activated T cells (NFAT), controls many aspects of T cell function. Here, we demonstrate that the calcineurin/NFAT pathway negatively regulates the expression of cyclin-dependent kinase 4 (CDK4). A canonical NFAT binding site was identified and found to be sensitive to calcium signals, FK506/CsA, and histone deacetylase activity and to not require AP-1. Ectopic expression of NFATc2 inhibited the basal activity of the human CDK4 promoter. Additionally, both calcineurin Aalpha(-/-) and NFATc2(-/-) mice had elevated protein levels of CDK4, confirming a negative regulatory role for the calcineurin/NFAT pathway. This pathway may thus regulate the expression of CDK4 at the transcriptional level and control how cells re-enter a resting, nonproliferative state. |
