| First Author | Tehrani S | Year | 2007 |
| Journal | Proc Natl Acad Sci U S A | Volume | 104 |
| Issue | 29 | Pages | 11933-8 |
| PubMed ID | 17606906 | Mgi Jnum | J:248259 |
| Mgi Id | MGI:6093104 | Doi | 10.1073/pnas.0701077104 |
| Citation | Tehrani S, et al. (2007) Src phosphorylation of cortactin enhances actin assembly. Proc Natl Acad Sci U S A 104(29):11933-8 |
| abstractText | Src kinase mediates growth factor signaling and causes oncogenic transformation, which includes dramatic changes in the actin cytoskeleton, cell shape, and motility. Cortactin was discovered as a substrate for Src. How phosphorylation of cortactin can enhance actin assembly is unknown. Here, using an actin assembly system reconstituted from purified components, we demonstrate for the first time a biochemical mechanism by which Src phosphorylation of cortactin affects actin assembly. The adaptor Nck is an important component of the system, linking phosphorylated cortactin with neuronal WASp (N-WASp) and WASp-interacting protein (WIP) to activate Arp2/3 complex. |
