| First Author | Yamaguchi M | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 1 | Pages | 28-34 |
| PubMed ID | 24269682 | Mgi Jnum | J:204662 |
| Mgi Id | MGI:5538412 | Doi | 10.1016/j.febslet.2013.11.015 |
| Citation | Yamaguchi M, et al. (2014) An anti-interferon activity shared by paramyxovirus C proteins: Inhibition of Toll-like receptor 7/9-dependent alpha interferon induction. FEBS Lett 588(1):28-34 |
| abstractText | Paramyxovirus C protein targets the host interferon (IFN) system for virus immune evasion. To identify its unknown anti-IFN activity, we examined the effect of Sendai virus C protein on activation of the IFN-alpha promoter via various signaling pathways. This study uncovers a novel ability of C protein to block Toll-like receptor (TLR) 7- and TLR9-dependent IFN-alpha induction, which is specific to plasmacytoid dendritic cells. C protein interacts with a serine/threonine kinase IKKalpha and inhibits phosphorylation of IRF7. This anti-IFN activity of C protein is shared across genera of the Paramyxovirinae, and thus appears to play an important role in paramyxovirus immune evasion. |
