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Publication : Expression of serpinb6 serpins in germ and somatic cells of mouse gonads.

First Author  Charron Y Year  2006
Journal  Mol Reprod Dev Volume  73
Issue  1 Pages  9-19
PubMed ID  16175637 Mgi Jnum  J:104412
Mgi Id  MGI:3611953 Doi  10.1002/mrd.20385
Citation  Charron Y, et al. (2006) Expression of Serpinb6 serpins in germ and somatic cells of mouse gonads. Mol Reprod Dev 73(1):9-19
abstractText  The serpin superfamily of serine protease inhibitors is implicated in the regulation of numerous physiological processes. In mice, Spi3/Serpinb6 has a broad tissue distribution. We have investigated the expression of Serpinb6 family members in embryonic and adult gonads. In male and female mice, Spi3/Serpinb6 and NK13/Serpinb6b were expressed in developing gonads and in both somatic and germ cells of adult gonads. By contrast, gonadal expression of Spi3C/Serpinb6c was sexually dimorphic and restricted to male germ cells and female somatic cells. These observations raise the question of the possible role(s) of the Serpinb6 family members in gonad development, gametogenesis, and/or fertilization.
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