| First Author | Ishii S | Year | 2005 |
| Journal | J Biol Chem | Volume | 280 |
| Issue | 10 | Pages | 9083-7 |
| PubMed ID | 15618224 | Mgi Jnum | J:154837 |
| Mgi Id | MGI:4399025 | Doi | 10.1074/jbc.M407832200 |
| Citation | Ishii S, et al. (2005) Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. J Biol Chem 280(10):9083-7 |
| abstractText | T cell death-associated gene 8 (TDAG8) is a G-protein-coupled receptor mainly expressed in lymphoid organs and cancer tissues. TDAG8 shares high amino acid sequence homologies with recently reported proton-sensing G-protein-coupled receptors, G2A, OGR1, and GPR4. Here we have identified TDAG8 as a novel proton-sensing receptor. Upon acid stimulation, stably expressed TDAG8 was internalized from the plasma membrane. As a signaling pathway downstream of TDAG8, accumulation of cyclic AMP was observed in response to solutions with a pH value lower than 7.2. Furthermore, RhoA activation and actin rearrangement were elicited by acid-stimulated TDAG8. These results suggest that TDAG8 may play biological roles in immune response and cellular transformation under conditions accompanying tissue acidosis. |
