| First Author | Kapur M | Year | 2012 |
| Journal | EMBO Rep | Volume | 13 |
| Issue | 11 | Pages | 1021-9 |
| PubMed ID | 22995871 | Mgi Jnum | J:200474 |
| Mgi Id | MGI:5508703 | Doi | 10.1038/embor.2012.140 |
| Citation | Kapur M, et al. (2012) Calcium tips the balance: a microtubule plus end to lattice binding switch operates in the carboxyl terminus of BPAG1n4. EMBO Rep 13(11):1021-9 |
| abstractText | Microtubules (MTs) are integral to numerous cellular functions, such as cell adhesion, differentiation and intracellular transport. Their dynamics are largely controlled by diverse MT-interacting proteins, but the signalling mechanisms that regulate these interactions remain elusive. In this report, we identify a rapid, calcium-regulated switch between MT plus end interaction and lattice binding within the carboxyl terminus of BPAG1n4. This switch is EF-hand dependent, and mutations of the EF-hands abolish this dynamic behaviour. Our study thus uncovers a new, calcium-dependent regulatory mechanism for a spectraplakin, BPAG1n4, at the MT plus end. |
