| First Author | Ivan M | Year | 2001 |
| Journal | Science | Volume | 292 |
| Issue | 5516 | Pages | 464-8 |
| PubMed ID | 11292862 | Mgi Jnum | J:210941 |
| Mgi Id | MGI:5572900 | Doi | 10.1126/science.1059817 |
| Citation | Ivan M, et al. (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292(5516):464-8 |
| abstractText | HIF (hypoxia-inducible factor) is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability. In the presence of oxygen, HIF is targeted for destruction by an E3 ubiquitin ligase containing the von Hippel-Lindau tumor suppressor protein (pVHL). We found that human pVHL binds to a short HIF-derived peptide when a conserved proline residue at the core of this peptide is hydroxylated. Because proline hydroxylation requires molecular oxygen and Fe(2+), this protein modification may play a key role in mammalian oxygen sensing. |
