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Publication : Expression of Arnt and Arnt2 mRNA in developing murine tissues.

First Author  Aitola MH Year  2003
Journal  J Histochem Cytochem Volume  51
Issue  1 Pages  41-54
PubMed ID  12502753 Mgi Jnum  J:81291
Mgi Id  MGI:2448795 Doi  10.1177/002215540305100106
Citation  Aitola MH, et al. (2003) Expression of arnt and arnt2 mRNA in developing murine tissues. J Histochem Cytochem 51(1):41-54
abstractText  The basic helix-loop-helix (bHLH-PAS) proteins aryl hydrocarbon receptor nuclear translocator (Arnt) and Arnt2 are transcriptional regulators that function as dimerizing partners for several bHLH-PAS proteins and also some nonrelated partners. They are involved in various biological functions, including regulation of developmental genes. In earlier studies, the developmental expression of Arnt was reported to be almost ubiquitous, whereas Arnt2 expression has been shown to be more limited, comprising neuronal tissues as the main site of expression. Here we provide a detailed description of the expression of Arnt and Arnt2 mRNA in mouse tissues during embryonic and early postnatal development. Arnt and also Arnt2 transcripts, in contrast to earlier reports, are shown to be expressed more widely during development yet show a temporally and spatially specific pattern. (J Histochem Cytochem 51:41-54, 2003)
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